The invention discloses mugilogobius chulae growth compound feed and a preparation method thereof. The feed is prepared from, by weight, 35-75 parts of white fish meal, 5-20 parts of bean pulp, 0-5 parts of fish oil, 0-8 parts of soybean oil, 0-35 parts of potato starch, 0.2-1 part of choline chloride, 1-3 parts of carboxymethylcellulose and 0.3-3.8 parts of microcrystalline cellulose. Compared with put biological baits, the mugilogobius chulae growth compound feed is convenient to put and store, and there is no need to independently cultivate artemia and other biological baits; the morbidity of mugilogobius chulae can be reduced, and the breeding requirements of experimental animals can be ensured to the maximum extent; raw material sources can be controlled, components are clear, and standardized quality control is convenient.