The invention provides a liquid crystal composition and a liquid crystal display device with the same. The liquid crystal composition is prepared from, by weight, 1% to 45% of at least a compound with the first general formula (please see the specification), 1% to 45% of at least a compound with the second general formula (please see the specification) and 10% to 70% of at least a compound with the third general formula (please see the specification). By means of the liquid crystal composition, low optical aeolotropy, high dielectric aeolotropy, low viscosity, the high clearing point, good low-temperature storage stability, good UV-resistance stability, good high-temperature stability and other characteristics can be achieved. The liquid crystal composition is suitable for the liquid crystal display device, and therefore the liquid crystal display device is high in reliability and can normally work in the severe environment.