The invention relates to a preparation method of a high-wear-resistant and anti-fouling seat fabric. The method comprises the steps that an anti-fouling finishing agent, friction fastness improvement components and water are mixed and then stirred, and a finishing liquid is obtained, wherein the anti-fouling finishing agent is composed of modified nano-silica hydrosol fluoride-free superhydrophobic components and acrylic acid-containing hydrophilic components; the seat fabric is soaked in the finishing liquid, two dipping and two rolling, drying and baking are conducted, and the high-wear-resistant and anti-fouling seat fabric is obtained. According to the preparation method of the high-wear-resistant and anti-fouling seat fabric, the method is simple, the cost is low, and ecological environmental protection is achieved; the obtained seat fabric has very good wear resistance, the requirement of automobile interiors always subjected to wear is met, and a wide application and popularization value is achieved.