The invention provides a chemical flooding numerical reservoir simulation method. The chemical flooding numerical reservoir simulation method comprises the following steps: step 1, performing optimal design of a network model, and establishing a static model; step 2, establishing a dynamic model on the basis of the established static model; step 3, adjusting parameters at different times on the basis of establishing the dynamic model to realize different-time history matching, wherein the mainly adjusted parameters are different at different times, and the demands on the matching precisions of different layers are also different. The chemical flooding numerical reservoir simulation method improves the numerical simulation software application level, as well as the reservoir description precision, and provides a more accurate technical support for later-period reservoir exploitation.