The invention provides a drilling well leakage prediction method based on digital rock masses. The method comprises the steps that borehole trajectory data of a current well is collected to acquire coordinates of all positions of a borehole trajectory; geological parameter information of all the positions is acquired from the digital rock masses of the current well according to the coordinates of all the positions in the borehole trajectory; engineering parameter information of all the positions is acquired according to the coordinates of all the positions in the borehole trajectory; drilling well leakage risk values of the positions are acquired according to the geological parameter information and the engineering parameter information of all the positions. According to the method, well leakage risk prediction can be conducted on the whole drilling well segment on the basis of related geological parameters and drilling engineering parameters, the method not only can be used for evaluating and optimizing a drilling design scheme but also can be used for identifying a well leakage trend in time in the drilling construction process, and therefore well leakage is avoided to the maximum limit.