The invention relates to a multi-file automatic layout combining method and device. The method comprises the steps that on the basis of paper parameters supported by a current printer, corresponding template files are selected from a preset template file library; printing production parameters corresponding to each file to be printed of all files to be printed are matched with preset printing production parameters of the template files; the files to be printed corresponding to the successfully-matched printing production parameters are adopted as files of the layouts to be combined; on the basis of preset layout combination rules in the template files, overall or partial files are selected from files of layouts to be combined are subjected to layout combination to obtain large layouts. The files of the layouts to be combined are input to the template files for automatic layout combination treatment to obtain the large layouts, and the defect that artificial treatment efficiency is low, the cost is high, and errors are easy to made is overcome. Meanwhile, the created template files can be repeatedly used, furthermore, waste of human resources of the actual production operation is further lowered, and the production efficiency is effectively improved.