The invention discloses a method and system for automatic typesetting of 3D printed models. By inputting 3D models needing to be printed into a computer, dimension parameters of the 3D models are obtained, and the system carries out automatic typesetting optimization according to preset conditions. Manual typesetting is replaced with automatic typesetting, so that time and labor are saved, efficiency is greatly improved, printing accuracy is high, component checking is not needed after printing, and printing is convenient and fast.