The invention relates to teaching experiment tools for petroleum and natural gas engineering specialty, in particular to an experiment device for simulating influence of external factors on migration and accumulation of water-soluble gas. The experiment device comprises a transparent box body, wherein a residual gas discharge hole is formed in a top cover of the transparent box body; a simulated water inlet pipe, a simulated natural gas inlet pipe, an electric heater, a pressurization structure, a pressure detector and a temperature detector are fixed on side walls of the transparent box body; a gas outlet of the simulated natural gas inlet pipe is communicated with an inner cavity of the transparent box body; a groove I is formed in a pipe section of a gas inlet end of the simulated natural gas inlet pipe; one end of a silicone pipe is fixed in the groove I through a binding wire or a rope; a gas inlet of a connecting pipe is communicated with a natural gas source. Due to the structure, the experiment device provided by the invention can be used for intuitive teaching and is easy to operate.