The invention relates to the field of food preparation and discloses a device for breaking crystallization nuclei in honey. The device comprises a spiral tube, wherein an inlet is formed in the upper end of the spiral tube, an outlet is formed in the lower end of the spiral tube, and a pump is installed on the inlet; the spiral tube comprises a filter section, a vacuum concentration section and a heat insulation section from top to bottom, a filter screen for filtering particles is arranged in the filter section, and valves are arranged at the two ends of the vacuum concentration section; a straight cylinder is arranged on the vacuum concentration section and communicated with the vacuum concentration section, a piston is connected in the straight cylinder in a sliding mode, and a first electric heating device is arranged in the straight cylinder; a one-way waterproof ventilation valve is arranged on the side wall of the straight cylinder, a second electric heating device is arranged in the heat insulation section, the two electric heating devices are both controlled by a temperature sensor and an electromagnetic switch so that overheating can be prevented, and an integral ultrasonic generator which is 28-40 KHz is arranged in the heat insulation section. According to the device, crystallization nuclei in honey can be broken continuously on the premise that the activity of active enzymes in honey is not affected, cost for breaking crystallization nuclei in honey is reduced, and noise pollution is avoided.