The invention discloses a pair of disposable slippers. The disposable slippers are of novel structures; automatic flow line production can be realized; the disposable slippers have the effects of disposability and preventing repeated use. Each of the disposable slippers disclosed by the invention comprises a slipper body and an upper; each upper is made of a pleated fabric which has longitudinal creases; a temporary suture line is arranged at the opening part of each upper, so that the pleated fabric is smooth when the slippers are not used; each upper and the corresponding slipper body form a layered fit state; various parts of each upper and the corresponding slipper body are connected through ultrasonic point welding so as to form a suture line. The invention further discloses a manufacturing method of the slippers; the core contents of the manufacturing method are that reprocessing is performed after flake overlapping is performed; the link of suturing the uppers manually is cancelled thoroughly; efficient production of a flow line can be realized; the disposable slippers is particularly applicable to ultrasonic tool processing.