An andrographolide enteric pellet-specific preparation is characterized in that the preparation comprises a blank pellet core, a medicine layer and an enteric coating layer, and the medicine layer comprises andrographolide and a polymer a dissolved at a pH value being not smaller than 7.0; a weight ratio of andrographolide to the polymer a is 1:2-1:0.2, and the weight gain of the medicine layer is 20-100 wt%; and the enteric coating layer comprises a polymer b dissolved at a pH value being not smaller than 5.5, and the weight gain of the coating layer is 5-30 wt%.