The invention relates to a tasteless tilmicosin particle and a preparation method thereof. The tilmicosin particle is prepared from tilmicosin, inner layer coating materials, granulating auxiliary materials and outer layer coating materials. Every 100 parts of particles comprise in parts by weight, 5-25 parts of tilmicosin, 8-40 parts of inner layer coating materials, 20-80 parts of granulating auxiliary materials and 2-10 parts of outer layer coating materials, wherein the inner layer coating materials are combinations of one or two or more of stearin, hexadecanol and octadecanol, the granulating auxiliary materials are combinations of one or two of magnesium stearate and sodium carboxymethyl starch, and the outer layer coating materials are combinations of acrylic resin and lauryl sodium sulfate. The tilmicosin is secondarily wrapped, so that the tilmicosin is isolated from an external environment, bitter taste of the tilmicosin is covered, and feed palatability cannot be affected.