The invention discloses composition for treating headache and a preparation method of the composition. The preparation method comprises the following steps: (1) volatile oil is extracted from dahurian angelica root, biond magnolia flower, manchurian wildginger, Chinese ligusticum rhizome and rhizome of chuanxiong respectively or in combination, an aqueous liquid is filtered for standby application, the obtained volatile oil and fineleaf schizonepeta spike oil are combined for standby application, three medicines including kudzuvine root, motherwort fruit and glossy privet fruit are boiled with water, filtered and left to stand, dregs obtained through volatile oil extraction are combined with dregs of the kudzuvine root, the motherwort fruit and the glossy privet fruit, water is added for extraction, the mixture is filtered, three filtrates are combined, left to stand and filtered, and a filtrate is condensed under vacuum, dried and ground into fine powder for standby application; (2) solid dispersion is prepared from the volatile oil and a water-soluble base with a proper method; (3) extract powder and the solid dispersion of the volatile oil are evenly mixed, auxiliary materials including a disintegrant, an adhesive, a diluent and the like are added, granules are prepared with a proper granulation method, and tableting is performed. The loss of the volatile oil in a prescription is reduced, the medicinal cure effect is improved, the medicine dissolution rate is increased through the preparation of the solid dispersion, and the onset time of volatile components in a preparation is shortened.