The invention discloses a pill packing machine provided with a clamping device. The pill packing machine comprises a cabinet body, vibration disc units, a film discharging device, a synchronous sealing device and the clamping device, wherein the vibration disc units comprise a first vibration disc unit and a second vibration disc unit; the vibration disc units are fixed on the upper end surface of the cabinet body; the material outlets of the vibration disc units are provided with induction counting units; the film discharging device and the synchronous sealing device are arranged on the left end surface of the cabinet body from top to bottom; a receiving component is arranged between the material outlets of the vibration disc units and the film discharging device; and the clamping device is arranged below the synchronous sealing device. By adopting the pill packing machine, pills of two different kinds can be mixedly packed in the same packing bag; the inner film unit and the outer film unit of the synchronous sealing device act synchronously, so that tidiness and attractiveness of the appearance of the packing bag are ensured; the stability of positions of an inner film and an outer film is further ensured due to the existence of the clamping device; and subsequent storage function of the packing bag is realized.