The invention discloses a comprehensive utilization method of ore with high contents of aluminum, silicon and iron. By using a reinforced leaching technology for rising leaching temperature by increasing a sulfuric acid concentration, valuable element and aluminum are leached efficiently; the silicon in the ore is purified to form an amorphous silicon dioxide product; the aluminum is separated to form an aluminum ammonium sulfate product via a crystallization method by adding an ammonium source; the valuable elements such as scandium and titanium are extracted step by step by using a solvent extraction method; and waste acid is concentrated and returns for ore leaching, and is crystallized to form ferric sulfate and ferrous sulfate. According to the method, a matched pyrite acid making system is built, sulfuric acid is provided, waste hot steam is made full use as a heat source of various procedures, and ferric sulfate and ferrous sulfate generated in a concentration process of waste acid is returned to the acid making system to achieve comprehensive utilization of the iron; and the method can achieve high-efficiency comprehensive utilization, clean production and emission without tailings of mineral resources and energy sources.