The invention discloses a 3D warp-knitted spacer fabric mattress framework material and relates to mattresses. The material is provided with an upper surface layer, a lower surface layer and a middle connection layer; the upper surface layer is a composite fiber knitted surface layer, the lower surface layer is a composite fiber knitted surface layer, and the middle connection layer is at least two groups of core monofilament knitted layers. By the adoption of the weaving method that the upper surface layer and the lower surface layer have different meshes and big meshes and small meshes in different shapes are staggered on the same surface and a special after-treatment mode in combination with composite polyester fibers and hollow filaments, the problem that most common 3D mattresses are poor in supporting performance and hard to move and transport can be successfully solved, and it can be guaranteed that breathability and environmental health of a whole mattress are not affected at all. The 100% polyester fibers are applied, and through the special material and weaving process method, it can be guaranteed that the material has excellent supporting performance without influencing the breathability and environmental friendliness of the mattress. The material has excellent and stable supporting performance, excellent breathability and healthy environmental friendliness.