The invention discloses a device for eliminating near-end cross-talk in transmission of multiple copper wire pairs. The device comprises local ends and clients which cooperate with the local ends. The device further comprises a signal generator which is arranged at the side of the local ends and is used for generating synchronous clock signals with rising edges and falling edges for the local ends; FPGA (Field Programmable Gate Array) chips which are arranged at the local ends and connected with the signal generator so as to control the data transmission state of the local ends based on the received synchronous clock signals and are connected with the clients; and a storage mechanism connected with the FPGA chips. The invention provides a device for eliminating near-end cross-talk in transmission of multiple copper wire pairs and a method applying the device, so that different copper wire pair transmission systems can send and receive signals at the same time, the sent signals are prevented from interfering near-end receiving ends, the effective transmission bandwidth is improved, the access capability of residential customers, commercial customers and the like is improved.