The invention discloses a chrome slag detoxifying comprehensive utilization method. The chrome slag detoxifying comprehensive utilization method is characterized by comprising the following steps that (1) chrome slag generated when sodium chromate is prepared through a pneumatic fluidized column is subjected to filter pressing, then water at the temperature of 50-85 DEG C is added into the filter-pressed chrome slag, and chrome slag slurry is obtained, specifically, the granularity of the chrome slag is 200-700 meshes; (2) acid is added into the chrome slag slurry, a chrome slag slurry solution is obtained, the pH value of the chrome slag slurry solution is controlled to be 6.0-8.5, the chrome slag slurry solution is stirred sufficiently, and the chrome slag slurry is leached in the solution; (3) reducing agents such as ferrous sulfate and sodium pyrosulfite are added into the chrome slag slurry solution till the Cr<6+> content in the leached chrome slag slurry solution is lower than 1.2 ppm; and (4) the chrome slag slurry solution subjected to reduction treatment is pressed and dried through a filter press, and filter residues obtained after filter pressing are ferric oxide powder. According to the chrome slag detoxifying comprehensive utilization method, the technical purpose of chrome slag detoxifying can be achieved, the detoxified chrome slag is the ferric oxide powder, and the solid waste standard requirements are met.