The invention discloses a synthesis method of ferrocenoindanone compounds. The synthesis method comprises the following steps: sequentially adding an N-heterocyclic carbene-palladium compound, a 2-halo aryl ferrocene compound, acid, alkali and organic solvent, introducing CO gas for 10-15 minutes while stirring at room temperature, heating the reaction system to 100-120 DEG C in sealed manner, and then reacting for 10-15 hours; after the reaction is completed, performing rotary evaporation concentration and chromatographic separation to obtain the ferrocenoindanone compounds. The ferrocenoindanone compounds are compounds shown by general formula I. In the general formula I, R1 is hydrogen, C1-C16 alkyl, -OMe, -CF3 or halogen; and R2 is hydrogen or methyl. According to the invention, less catalyst is consumed, CO used as the starting material is cheap and accessible, favorable yield and substrate universality are achieved, and the yield is greater than 90% in most cases. The ferrocenoindanone compounds provided by the method have a very wide application range in the fields of organic catalysis, biochemistry, material chemistry and the like.