利索-全球专利检索

  1. 登录
  2. 注册
发明公开
CN106222176A 一种DNA分子及其在制备糖尿病鼠模型中的应用 无效 - 驳回

一种DNA分子及其在制备糖尿病鼠模型中的应用
摘要：
本发明公开了一种DNA分子及其在制备糖尿病鼠模型中的应用。本发明公开的DNA分子，包括表达盒甲和表达盒乙，表达盒甲用于表达猪11βHSD1基因，表达盒乙用于表达GIPRdn基因和hIAPP基因；猪11βHSD1基因编码序列表的序列2所示的蛋白质；GIPRdn基因编码序列表的序列3所示的蛋白质；hIAPP基因编码序列表的序列4所示的蛋白质。本发明通过向受体动物中导入本发明的DNA分子，进而得到了糖尿病动物模型，可利用糖尿病动物模型进行糖尿病机理的研究和药物的开发，具有广大的应用前景。
摘要（英）：

The invention discloses a DNA molecule and application thereof in preparing a diabetic rat model. The DNA molecule comprises an expression kit A and an expression kit B, wherein the expression kit A is used for expressing a pig 11beta HSD1 gene; the expression kit B is used for expressing a GIPRdn gene and an hIAPP gene; the pig 11beta HSD1 gene is used for encoding protein as shown in sequence 2 of a sequence table; the GIPRdn gene is used for encoding protein as shown in sequence 3 of the sequence table; the hIAPP gene is used for encoding protein as shown in sequence 4 of the sequence table. By introducing the DNA molecule into a receptor animal, a diabetic animal model can be obtained, and the diabetic animal model can be adopted for the study on diabetes mechanisms and the development of medicines, and has good application prospects.

0/0