The invention discloses a manufacturing method of light, thin and soft liner sheepskins. Softened and pickled skins obtained by a conventional process in the prior art serve as raw materials for deacidification, enzyme softening, repickling and tanning; and then, the aftertreatment is performed by the conventional process. The first time of pickling and softening is performed for raw skins in the blank skin preparation phase for removing interfibrillar substances and loosening collagenous fibers; and leathers become more uniform and rigid when softening in subsequent deacidification and enzyme softening. The invention provides a method for step-by-step treatment of sheepskins in bath foams with high and low PH values by characteristics of enzyme preparations, and multiple enzyme preparations are reasonably used step by step to generate cooperative effects, so that respective advantages of acid enzyme and alkali enzyme are fully exerted, the softening effect is greatly improved, and finished sheepskins are lighter, softer, firmer and more elastic. The prepared products are mainly used for liners of cotton wadded jackets, and can be used for producing collars, trimmings of various fashionable dresses and the like.