The invention relates to a resource allocation method based on clustering in a femtocell double-layer network. The resource allocation method comprises the steps of allocating sub-channels for MUEs (Macrocell User Equipments) by employing a three-round sub-channel allocation algorithm; according to a planning objective and constraint conditions for power allocation, allocating a power for the MUEs by adopting a typical water-filling algorithm; carrying out clustering on femtocells by adopting an improved GASA; according to rate requirements of FUEs (Femtocell User Equipments), allocating the sub-channels for the FUEs by adopting a heuristic algorithm; and carrying out power allocation on the FUEs by employing KKT (Karush-Kuhn-Tucker) conditions. According to the resource allocation method disclosed by the invention, on the premise of guaranteeing normal communication of the MUEs, the interference among the MUEs is minimized, the spectrum utilization efficiency is improved, and the service quality of the FUEs and the MUEs is guaranteed.