The invention provides a high-voltage wire inlet cabinet and self-generating cabinet interlocking device, belonging to the technical field of power equipment. The device comprises a high-voltage wire inlet cabinet and a self-generating cabinet. Both the cabinet door of the high-voltage wire inlet cabinet and the cabinet door of the self-generating cabinet are provided with latches, and a same key is used for the two latches. The circuit breaker support of the high-voltage wire inlet cabinet is arranged on a support guide rail in a front and back sliding way. An upper moving contact and a lower moving contact are installed on a vacuum circuit breaker. An upper static contact is arranged on an upper contact box, and a lower static contact is arranged on the lower contact box. A small bus terminal is orderly connected to a secondary wire room, a secondary interlock and a vacuum circuit breaker. The upper static contact is connected to a three-phase terminal. The lower static contact is connected to one end of a current transformer. The other end of the current transformer is connected to a grounding knife and a cable. The cabinet door of the high-voltage wire inlet cabinet is also provided with a notch. One side of the support guide rail is provided with a limit locking component. A condition that the high-voltage wire inlet cabinet and the self-generating cabinet are at a working state at the same time can be effectively prevented, an accident is avoided, and the safety protection is good.