The invention provides a power plant AVC control substation simulation method which belongs to the field of electric power system dispatching automatic control and simulation technologies. The method comprises the steps that by taking five minutes as a regulation cycle, network topology analysis is used to acquire the list of generator sets which affect a controlled bus, and the voltage influence coefficient of the reactive power variation of each generator set to the controlled bus is calculated; according to the controllable reactive power margin of each generator set, the reactive power adjustment amount of each generator set is acquired by calculating the voltage deviation between the current value of the controlled bus and the voltage set value; when the absolute value of the voltage deviation is less than voltage allowable deviation, reactive power adjustment is not carried out; when the absolute value of the voltage deviation is greater than voltage allowable deviation, reactive power step-by-step adjustment is carried out on the generator sets, and the absolute value of the voltage deviation of the controlled bus is less than the voltage allowable deviation. The method provided by the invention has the advantages of realistic simulation effect and is advantageous to improving the actual collaborative control effect of the AVC of a main station and the AVC of a power plant substation.