The invention relates to a waterproof loopy yarn fabric with high safety. The fabric comprises a fabric body (1), wherein the surface of the fabric body is covered with a polyurethane film (2), the surface of the polyurethane film is covered with moisture-absorbing and sweat-removing fiber (3), ventilation holes are formed in the surface of the moisture-absorbing and sweat-removing fiber, the surface of the moisture-absorbing and sweat-removing fiber (3) is covered with a waterproof layer (4), and the surface of the waterproof layer (4) is covered with a polyurethane coating (5). The fabric body is formed by a textile fabric which is formed by interweaving of warp and weft, the warp comprises looping yarn and base yarn, and the looping yarn forms a fixed texture after crossing certain quantity of weft. The starting point and the finishing point of the loop formed by the looping yarn are separated by three pieces of weft; adjacent weaving points of the fixed texture formed by the base yarn are separated by three pieces of weft. According to the waterproof loopy yarn fabric with the high safety, the smoothness of the fabric can be improved, and the fabric is not easy to pollute and has waterproof and breathable effects. The product can be full, fluffy, soft and firm in hand feeling.