The invention discloses an olive bitter glycoside suppository. Medicine components of the suppository are bitter glycosides, components and proportions of substrates of the suppository are adjusted, and quick release suppositories and suppositories with medium release rate can be obtained. The suppository is supplied through a vagina and can be used for treating gynecological diseases such as vaginitis, pelvic infection and cervical erosion, the suppository is supplied through a rectum can be used for treating rectitis and rectal cancer, and the suppository can enter general blood circulation through a rectal mucosal lower vessel and has the functions of generalized inflammation resistance and osteoporosis improvement and the like.