The invention discloses a natural skin ointment. The natural skin ointment comprises safflower seeds, cotex dictamni, sophora flavescens, gallnut, fructus xanthii, herba schizonepetae, fructus cnidii, portulaca oleracea, radix angelicae, olibanum, myrrh, grape seeds and water. The invention also discloses a preparation method of the natural skin ointment. The preparation method of the natural skin ointment comprises the following steps: extracting procyanidine from the grape seeds by an ultrasonic extraction method; extracting safflower seed oil from the safflower seeds by a low-temperature cold-pressing method; adding water into cotex dictamni, sophora flavescens, gallnut, fructus xanthii, herba schizonepetae, fructus cnidii, portulaca oleracea and radix angelicae and decocting to obtain a first extracting solution; adding water into olibanum and myrrh and decocting to obtain a second extracting solution; mixing procyanidine, safflower seed oil, the first extracting solution and the second extracting solution, heating and boiling, maintaining slight boiling, stirring and cooling to obtain the natural skin ointment. The natural skin ointment provided by the invention has high anti-inflammatory, bacteriostatic and antioxidative effects, has a good treatment effect on various skin diseases and can promote skin regeneration.