The invention discloses a medicine sequential storage box and relates to the field of medical instruments. The medicine sequential storage box comprises a box body and a medicine frame used for placing medicines; the two sides in the box body are both provided with a chute and a slipway; guide flanges which extend into the corresponding chutes are arranged at the two ends of the medicine frame; a supporting table which presses on the slipways is arranged at the middle part of the medicine frame; and the medicine frame can move along the chutes and the slipways and is provided with a signboard. The medicine sequential storage box can solve the problems of sequential placement according to the expiry dates of medicines and inconvenience in medication when the medicines are placed in the storage box, thus the phenomenon that the medicines with preceding expiry dates are expired as not being timely used without being sequentially placed according to the expiry dates is prevented.