The invention discloses a production method of 20-20-0-13 sulfur-based compound fertilizer, and belongs to the technical field of compound fertilizer production. The method includes the steps that sulfuric acid, phosphoric acid, liquid ammonia and urea are added into a granulation device by the mass ratio of (5.8-6.2):(13.9-14.3):(3.8-4.2):(0.64-0.68), the neutralization degree is 1.60-1.66, the temperature of a spouting tank is kept over 80 DEG C, and the product is obtained after drying, screening and cooling. Sulfuric acid, phosphoric acid, liquid ammonia and urea are used for producing sulfur-based compound fertilizer, urea content is controlled to be at a low level, the temperature of a spouting tank is controlled to be over 80 DEG C, slurry is prevented from crystallizing in the spouting tank, the granulation process can be kept stable, the particle size is distributed from 2 mm to 4 mm, the fertilizer with the particle size being 2-4 mm accounts for 90% or more, the nitrogen content is larger than 19.5%, the phosphorus content is larger than 20%, the sulfur content is larger than 13.5%, and then strength can be higher than 33 N.