The invention relates to the field of medical chemistry, and aims at providing a substituted furan chalcone derivative and a preparation method thereof. The substituted furan chalcone derivative has the structure shown in a formula (I): wherein B ring is selected from phenyl, furyl or thienyl; R1, R2, and R3 are respectively and independently selected from hydrogen atom, halogen, hydroxyl, cyan, nitro, C1-C7 alkyl chain, C1-C7 alkoxy, and dimethylamino or diethylamino. The product is a kind of natural furan chalcone analogues with a new framework, the product has potential medicament activity, and the preparation of the compound can provide support for activity researches of furan chalcone medicaments. The preparation method has simple steps and low loss late, and provides a brand new route for synthesis of the furan chalcone derivative from nonaromatic raw materials. The method has an important meaning for industrial production.