Provided is a shaft seal device of a rotor pump. The shaft seal device comprises a mechanical seal base (3), a fixed ring (4), a moving ring base (5) and a moving ring (6) driven by the moving ring base (5). A first O-shaped ring (8) is arranged in a slit between the fixed ring (4) and the mechanical seal base (3). A tube body of the moving ring base (5) extends into the inner cavity of the mechanical seal base (3), an inner cavity (9) of the moving ring base, which is closed, is formed between the tube body of the moving ring base (5) and a shaft (1), a second O-shaped ring (11) is arranged in a slit between the moving ring (6) and the moving ring base (5). A compressive spring (12) is arranged between a connected end of the moving ring base (5) and the moving ring (6), and the moving ring (6) is in close contact with the fixed ring (4). A third O-shaped ring (30) is arranged between a connected end of the moving ring base (5) and the shaft (1). The moving ring base (5) is connected with an impeller (2) through at least one drive pin (13); one end of each drive pin (13) is in close-fit connection and the other end thereof is in floating insertion. By the shaft seal device of the rotor pump, performance of the rotor pump is improved and service life thereof is prolonged effectively. The shaft seal device is particularly applicable to shaft sealing of hygiene-grade rotor pumps.