The invention discloses a device and a method of intelligently checking main station-side power distribution automation signals. The device comprises an intelligent receiving and reading module, a measured end signal transmitting module, a duty-free electronic checking module, an electronic report generation module and an intelligent transmitting module. The method comprises steps: an e-mail is read and analyzed; a starting signal group, a checking ending signal group and a state ending signal group are transmitted; the signal groups are received; operation corresponding to the signals is carried out; a signal testing electronic report is generated; an electronic report file is generated; and the electronic report file is forwarded to a preset e-mail box of a responsible person. The checking device and the checking method only require the measured end operator to control the measured end signal transmitting module to transmit signals, unattended operation is realized at the main station side, and input of time and persons is reduced.