The present invention is to provide an adaptive method of clock controller and a device thereof, wherein the method is based on a clock controller, a conversion module, and a memory, and the memory is used to store original compensation data corresponding to a liquid crystal panel, and wherein the method comprises: capturing the original compensation data from the memory by the conversion module; converting the original compensation data into updated compensation data adapted to the clock controller by the conversion module; capturing the updated compensation data from the conversion module by the clock controller and outputting a screen compensated by the updated compensation data to a liquid crystal panel. By the above-mentioned manner, the present invention can adapt the same original compensation data to different clock controllers without changing the original compensation data in the memory.