The invention discloses a general surgical instrument cleaning device which comprises a flush tank, a conveyer, an ultrasonic cleaning chamber, a sterilizing chamber and a drying oven. A window is arranged on the front side of the flush tank; by combination of a detachable bracket, a first inwards-concave part disassembling plate and a second inwards-concave part disassembling plate, a surgical instrument can be rapidly and conveniently installed and disassembled, classification is automatically carried out after the surgical instrument is cleaned in the flush tank, the detachable bracket falls into a collection box, and the surgical instrument falls into a net bag so as to automatically and efficiently complete primary flushing work; a multi-enzyme detergent is arranged in the ultrasonic cleaning chamber, and by placing the net bag and the surgical instrument in the multi-enzyme detergent below a liquid level by 20mm for 8 minutes, deep cleaning can be completed so as to remove certain chemical substances in the surgical instrument together; remaining germs can be killed in the sterilizing chamber so as to provide guarantee for a patient which is operated later; complete evaporation of the drying oven on moisture is the last link of cleaning, and drying is carried out for 20 minutes at a temperature of 90 DEG C. The device is reasonable in design and has a better effect than a conventional device.