A multi-mixer system includes an amplifier module and a plurality of channels. The amplifier module is arranged for receiving signals from an antenna or antenna arrays to generate a plurality of radio frequency (RF) input signals. The plurality of channels are coupled to the amplifier module, wherein the plurality of channels receive the RF input signals, respectively, and each of the channels includes a mixer for mixing one of the RF input signals with a local oscillating signal to generate a mixed signal. In addition, at least one of the channels includes an interference reduction circuit positioned between the amplifier module and the mixer. By reducing the interference between the amplifier module and the mixer, the harmonics of the local oscillation signal can be filtered or isolated from other channels, and the performance of the mixer can be improved.