The invention provides a node replacement method and device in a distributed database, wherein the method comprises the following steps of: setting an original node to be in an unavailable state; setting a new node to have an IP address, which is the same as that of the original node; receiving a node replacement instruction, and judging the replaced node type according to the IP address in the instruction; and performing node replacement according to the node type. A node is replaced by setting the same IP address in the replacement process; furthermore, node replacement is carried out according to the node type; a cluster still can provide normal external services during the period; and thus, the process does not need to be interrupted.