The invention belongs to the technical field of agricultural herbicide, and particularly relates to a compound weeding composition containing terfuryltrione and cafenstrole. The effective components comprise terfuryltrione and cafenstrole, weight ratio of the terfuryltrione to the cafenstrole is 10:1-1:16, and preferential weight ratio of the terfuryltrione to the cafenstrole is 6:1-1:6. The compound formulated weeding composition shows remarkable synergism for annual weeds like barnyard grass of a paddy field, is composed of effective components of different action mechanism, and action site is increased, which is beneficial to overcoming and delaying generating of drug resistance of weeds, expanding weed control spectrum, increasing drug efficacy, reducing cost of production and use cost, and is effective for various grass weeds and broadleaf weeds of the paddy field.