The invention provides an electrode wire operating system for a wire cut electrical discharge machining device. The electrode wire operating system comprises an electrode wire storage frame, an electrode wire conveying frame and an electrode wire drive frame. A wire storage cylinder is arranged on the electrode wire storage frame and arranged on a supporting plate through a supporting column. A drive motor is arranged on the supporting plate. The bottom of the supporting column is fixedly connected with the supporting plate. A lead screw is arranged at the bottom of the supporting plate and connected with a servo motor. The supporting plate is driven by the servo motor to move on the lead screw. A pair of position sensors is arranged on a support. A pair of blocking strips is arranged on the edge of the supporting plate and arranged at the two ends of the supporting plate. When the blocking strips block the position sensors, the servo motor rotates reversely to drive the supporting plate to move in the reverse direction. An overrun sensor is arranged between the position sensors. When the position sensors fail, the blocking strips move continuously, when the blocking strips block the overrun sensor, a power source of the servo motor is forcibly cut off, flexible dustproof covers are correspondingly arranged at the two ends of the supporting plate, and the lead screw below the supporting plate is shielded through the flexible dustproof covers.