The invention discloses a peer-to-peer mutual replication method suitable for grid multiple-region integration. The control systems in regional mutual replication are in complete equal position, a grid model is shared according to regional distributed maintenance and needs, the operation information are in two-way synchronization, the real-time data is collected independently, in the condition that the data of two sides are consistent, a regional master back-up system realizes downlink control one-key online switch and integrated calculation analysis. By using the method, the expansibility and usability of a power grid control standby system can be improved.