The invention relates to a hose cryoprobe with a guide wire guiding device and a usage method. The hose cryoprobe comprises a refrigerant return air and guide wire channel tube with the right portion extending into a human body and a cold head arranged at the right end of the refrigerant return air and guide wire channel tube, wherein a guide wire for guiding the cold head to pass through an inner bent channel of the human body, an in-channel blocking tumor and/or an in-channel blocking lesion tissue to reach a diseased part. The hose cryoprobe has the advantages of being capable of achieving repeated treatment, making a patient have no pain, being low in cost, simple in operation and same in treatment effect and bringing few complications.