Relating to the technical field of leather degreasing, the invention provides a composite lipase degreasant and application. The composite lipase degreasant is prepared from, by weight, 15-25 parts of lipase and 10-15 parts of surfactant. The lipase is neutral lipase or alkali lipase; the surfactant is a sulfonate surfactant, polyoxyethylene ether surfactant or or a plurality of sulfonate surfactants and polyoxyethylene ether surfactants. The composite lipase degreasant and application, by synergistic effects of the lipase and surfactant, enhances the degradation of lipase to grease and makes intracutaneous grease easily eluted from crust so as to reach highly efficient degreasing effects. Applicable to degreasing all kinds of animal skins, such as pigskin, sheepskin, goat skin and buffalo hide, the composite lipase degreasant and application has mild skin effects, which is economical, eco-friendly and applicable to degreasing in different procedures.