It is a time division interference alignment method for full-duplex base station cellular network, which transmits signal of the up-link and down-link users through two time slots, and combines the receipt signal of down-link users. Space of obtained down-link signal is double of the antenna number. Therefore, the method can be used for interference alignment of both multi-antenna users and single antenna users. In the transmission process, the base station makes interference alignment of up-link to down-link users and that among down-link users in the same space. The up-link user does not need to be pre-coded, that is, it does not need to obtain the global channel state information.The invention enhances the interference alignment compatibility of multi-antenna users and the single antenna users, and reduces the difficulty of accessing the channel status information for up-link users.