The invention discloses a high-strength high-toughness self-sensing intelligent ceramic needle knife, which comprises six signal lamps, a data processing module, a power supply, a handle, a straight knife bar, a signal transmission wire, a resistance detection module and a tool bit bar, wherein the resistance detection module is arranged between the straight knife bar and the tool bit bar; a force sensor is arranged inside the resistance detection module; the six signal lamps respectively represent that a knife edge at the end part of the knife head bar enters different tissue layers of the human body. The resistance received by the knife edge at the end part of the knife head bar in the advancing process in the human body tissues is measured by the force sensor; data measured by the force sensor is transmitted to the data processing module by the signal transmission wire; after the data is processed by the data processing module, the corresponding signal lamps are controlled to be turned on. Therefore the self-sensing intellectualization of the needle knife control is realized; the problem of treatment accident occurrence due to experience lack of some doctors is solved.