The invention discloses an inorganic hybrid amino resin represented by at least one selected from a formula (I), a formula (II) and a formula (III). In the above formulas, M represents one group selected from -B(OH)-, -Sb(OH)- or -Mo(=O)2-; R represents a substituent group of a monohydric alcohol or a polyhydric alcohol with one less hydroxide radical; and R1 represents a substituent group of a monohydric alcohol with one less hydroxide radical. The invention also discloses a synthetic method of the above inorganic hybrid amino resin. The method comprises the steps of adopting hexamethylol melamine as a raw material and a monohydric alcohol as a solvent, subjecting the above materials and an etherification reagent to etherification reaction at 40-43 DEG C, adding a solution of a hybridization reagent into the reaction solution obtained during the above step, subjecting the solution to hybridization reaction, and finally adding a polyhydric alcohol as required for conducting the ester exchange reaction. Compared with conventional amino resins, the inorganic hybrid amino resin is further improved in flame resistance and temperature tolerance. Meanwhile, the solubility of the inorganic hybrid amino resin for polar compounds is improved.