The invention relates to the field of oil production engineering and belongs to a large-scale anti-back-spattering sand blower for the oil tube fracturing, which can be used for solving the problems that a sand blower is poor in abrasion resistance and is worn due to back-spattering sandblasting in an oil tube fracturing process in the past. The large-scale anti-back-spattering sand blower comprises an upper joint (1), a filter screen (2), a nozzle (3), a pressure guide body assembly (4), an anti-rotation pin bolt (5), a lining (6), an alloy gasket (7), a rubber protecting jacket (8), an alloy protecting ring (9), an alloy spacer (10), a rubber protecting piece (11), a fixed pin bolt (12), an aligning body (13), rubber spacers (14) and slot bodies (15). The large-scale anti-back-spattering sand blower is mainly applied to large-scale fracturing processes and has the advantages of excellent temperature resistance and pressure resistance, safe and reliable process and the like.