The invention relates to a temporary plugging steering acidification method applicable to a sandstone reservoir, which belongs to the technical field of yield increasing and injection increasing of oil and gas fields. By adopting pad-acid and synergistic liquid, the temporary plugging of a high permeable layer of the non-homogenous sandstone reservoir can be realized, and the temporary plugging performance is good, so that the subsequently injected main body acid liquid can be successfully diverted to enter a low permeable layer and to acidify the low permeable layer. By adopting the acidification method, the sandstone reservoir can be effectively and homogenously acidified, and the non-homogeneity of the reservoir can be improved.