The invention discloses a medical isotope production reactor with uranium fuel saving. The main structural characteristics of the medical isotope production reactor are that a concentrated liquid overflow port is added in an acidication tank, a liquid discharge quantity indication tank is connected through a pipeline, the bottom pipeline of the liquid discharge quantity indication tank is connected to the feed liquid discharge pipeline of a core vessel, from an acidication tank concentrated liquid overflow port pipeline, by way of a liquid discharge quantity indication tank, the washing water discharge pipeline of the liquid discharge quantity indication tank, the feed liquid discharge pipeline connected to the core vessel, after accessing and washing a medical isotope extraction column and discharging washing water into a storage tank, a washing water pipeline system of acidication tank washing extraction column is formed. By using the system, after starting and stopping the reactor to carry out isotope extraction in each time, the feed liquid is stored in the storage tank, then by using the system, the washing water with remaining uranium after washing the extraction column is discharged into the storage tank, the washing water and the feed liquid with isotope extraction in the tank are mixed, in a next time of starting the reactor, dilute feed liquid is concentrated to the initial fuel concentration of a previous time of reactor starting, and a lot of uranium fuels are saved in the life cycle of 20 years of the reactor.