The invention discloses a low-voltage side positive sequence clockwise and negative sequence anticlockwise compensation method for differential protection of transformers. For differential protection of transformers of all 12 wiring groups, a high-voltage side eliminates zero sequence current in the phase current, and the a phase, b phase and c phase of the low-voltage side are decomposed into positive sequence current and negative sequence current to automatically eliminate zero sequence current. Each phase of positive sequence current rotates n*30 degrees clockwise with the low-voltage side as the reference to be consistent with the phase of each phase current of the high- voltage side. Each phase of negative sequence current rotates n*30 degrees anticlockwise with the low-voltage side as the reference to be consistent with the phase of each phase current of the high- voltage side. The method is applicable to longitudinally differential protective devices of transformers, of which the low-voltage sides belong to any 1-12 points combination wiring groups, and completely meets the requirements for current phase compensation of differential protection of a transformer.