The invention provides a spiral piece flow guiding type phase separation device. The spiral piece flow guiding type phase separation device comprises a separation tube. The separation tube is sequentially divided into a mixing section, a swirl section, a separation section and a discharging section according to effect regions, wherein the mixing section is internally provided with a static mixer which is used for fully mixing input liquid; a swirler is installed in the swirl section; the liquid passing the swirl section can be fully separated into an inner swirl field and an outer swirl field under the action of the centrifugal force in the separation section; and the discharging section comprises a heavy-phase discharging tube which is located at the end of the separation tube and a light-phase discharging tube of which one end is inserted into the swirl section along the axis line of the separation section and the other end penetrates through the side wall of the separation tube. The spiral piece flow guiding type phase separation device has the advantages of being small in device size, light in weight, high in separation efficiency and the like and is applicable to various occasions where two-phase mixed fluid different in density needs to be separated in the industrial production process, so that the technical requirement of the technological process is met, product purification is completed or useful raw materials are recycled, and the industrial application prospects are good.