The invention discloses a can sterilization cage with rolling wheels. The can sterilization cage comprises a plurality of overlaid square cases, frames and bottom face plates of the square cases are all made of stainless steel materials, positioning grooves are formed in the four corners of the top surface of each square case, positioning blocks are arranged at the four corners of the bottom surface of each square case, and the positioning blocks on the square cases on the upper layers are inserted into the positioning grooves in the square cases on the lower layers. A plurality of can pressing devices are arranged on each square case side by side, and each can pressing device is composed of a pushing block, a pressing block, a screw rod and an adjusting handle. The rolling wheels are arranged at the four corners of the bottom of the bottommost square case. A plurality of long-strip-shaped ventilation holes distributed up and down are formed in the four walls of each frame. After the square cases are fixedly connected through fixing pins, the can sterilization cage can be conveniently pushed into a horizontal type sterilization pot; and since the multiple long-strip-shaped ventilation holes distributed up and down are formed in the four walls of each frame, the ventilation performance of the square cases is greatly improved, and a good sterilization effect is achieved.